Welcome to the MitoBreak database project

A comprehensive on-line resource with curated datasets of mitochondrial DNA (mtDNA) rearrangements. MitoBreak provides a complete, quality checked and regularly updated list of breakpoints from: circular deleted mtDNAs (deletions) circular partially-duplicated mtDNAs (duplications) linear mtDNAs For more background information click here or read Damas J, et al. Nucleic Acids Research. 2014. 42 (D1): D1261-D1268.

What can be found in MitoBreak Taxonomy Number of rearrangements Reference sequence Number of publications Kingdom Phylum Species Metazoa Chordata Homo sapiens 805 deletions + 44 duplications NC_012920.1 358 Metazoa Chordata Mus musculus 245 deletions + 31 short linear breaks NC_005089.1 24 Metazoa Chordata Rattus norvegicus 215 deletions NC_001665.2 13 Metazoa Chordata Macaca mulatta 58 deletions NC_005943.1 4 Metazoa Arthropoda Drosophila melanogaster 35 deletions NC_001709.1 2 Fungi Ascomycota Podospora anserina 32 deletions NC_001329.3 1 Metazoa Nematoda Caenorhabditis elegans 6 deletions NC_001328.1 2 Total 1471 (1396 deletions + 44 duplications + 31 linear)

What can be done in MitoBreak Explore Download Filter Compare Find references Submit data Publish Investigate our curated datasets of mtDNA breakpoints with multiple statistical tools Copy our curated datasets of mtDNA breakpoints to your computer and analyse them as you wish! Examine (or download) only selected subsets of our databases, e.g., disorders, strains… Locate your breakpoints in our large datasets. Are they unique? In which disorders where they previously found? Find an updates list of publications for each rearrangement type and species, with links to PUBMED Share new mtDNA rearrangements with the research community Download high-quality graphs ready for publication!

Latest news 2 September 2016 MitoBreak is now available at OMICtools. 26 May 2014 The MitoBreak data can be found on the Mitochondrial Disease Sequence Data Resource (MSeqDR) Consortium. 2 April 2014 MitoBreak registry on Orphanet - The portal for rare diseases and orphan drugs. 3 March 2014 Unpublished datasets can now be analysed using MitoBreak. 30 December 2013 MitoBreak: The mitochondrial DNA breakpoints database. Damas J, et al. Nucleic Acids Research. 2014. 42 (D1): D1261-D1268 NAR database 2014 issue. 27 September 2013 Unpublished data can now be submitted to mitobreak. 23 September 2013 It is now possible to download the flanking sequences of all breakpoints in the Dataset section. June 2013 A fully operational version of the MitoBreak database is now publically available.

Direct links

• Human 'common deletion' page
• General statistics for the 805 human mtDNA deletions
• Filtered dataset of deletions from Kearns-Sayre Syndrome (KSS), Progressive External Ophtalmoplegia (PEO) or Pearson Marrow-Pancreas Syndrome (PS)
• Examples of deletions for the mitochondrial mutator mice
• List of deletions from aging Drosophila melanogaster