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7819 - 16077
Homo sapiens - Deletions

Deletion length: 8257 bp

Does not remove any origin of replication
Inside the major arc



Breakpoint flanking sequences
more information in Documentation - Flanking regions


7819
5fl vs 3del
Homology length: 2 bp

Deleted region


16077
TCCTAGTCCTCATCGCCCTC 5'Breakpoint CCATCCCTACGCATCCTTTA (...) CAAGTATTGACTCACCCATC 3'Breakpoint AACAACCGCTATGTATTTCG
5del vs 3del
Homology length: 5 bp

TCCTAGTCCTCATCGCCCTC 5'Breakpoint CCATCCCTACGCATCCTTTA (...) CAAGTATTGACTCACCCATC 3'Breakpoint AACAACCGCTATGTATTTCG




Two-dimensional scatterplot showing the location of the selected deletion (red diamond) versus the full dataset (grey dots). Each point represents an mtDNA rearrangement with the 5’ breakpoint on the x-axis and the 3’ breakpoint on the y-axis.

Circular mtDNA plot specifying the location of the deleted region (black bar).
Length distribution of the deleted region in the selected deletion (red bar) versus the full dataset (grey bars) .The cases were grouped 100-nt windows.
Present in:
ad/ar-PEO
Aged tissues

References

 [14] Eshaghian, A., et al., Mitochondrial DNA deletions serve as biomarkers of aging in the skin, but are typically absent in nonmelanoma skin cancers. Journal of Investigative Dermatology. 2006. 126(2): p. 336-44.

 [15] Regan, C., Sequence characterization of breakpoint regions of human mitochondrial DNA deletions and possible mechanisms of formation. PhD Thesis. 1999.