7819 - 16077 Homo sapiens - Deletions Deletion length: 8257 bp Does not remove any origin of replication Inside the major arc	Breakpoint flanking sequences more information in Documentation - Flanking regions
	7819 5fl vs 3del Homology length: 2 bp Deleted region 16077 TCCTAGTCCTCATCGCCCTC ├ 5'Breakpoint ┤ CCATCCCTACGCATCCTTTA (...) CAAGTATTGACTCACCCATC ├ 3'Breakpoint ┤ AACAACCGCTATGTATTTCG 5del vs 3del Homology length: 5 bp TCCTAGTCCTCATCGCCCTC ├ 5'Breakpoint ┤ CCATCCCTACGCATCCTTTA (...) CAAGTATTGACTCACCCATC ├ 3'Breakpoint ┤ AACAACCGCTATGTATTTCG

Two-dimensional scatterplot showing the location of the selected deletion (red diamond) versus the full dataset (grey dots). Each point represents an mtDNA rearrangement with the 5’ breakpoint on the x-axis and the 3’ breakpoint on the y-axis.	Circular mtDNA plot specifying the location of the deleted region (black bar).
Length distribution of the deleted region in the selected deletion (red bar) versus the full dataset (grey bars) .The cases were grouped 100-nt windows.

Present in:
ad/ar-PEO
Aged tissues

References

 [14] Eshaghian, A., et al., Mitochondrial DNA deletions serve as biomarkers of aging in the skin, but are typically absent in nonmelanoma skin cancers. Journal of Investigative Dermatology. 2006. 126(2): p. 336-44.

 [15] Regan, C., Sequence characterization of breakpoint regions of human mitochondrial DNA deletions and possible mechanisms of formation. PhD Thesis. 1999.